SAMe (often mispronounced unless spelled SAM-e) is an acronym for S-adenosyl methionine — i.e, the amino acid methionine linked
to the DNA base adenosine. SAMe plays a role in sulfur metabolism.
SAMe deficiencies would result from deficiencies of the factors or cofactors required to make it — methionine, choline, or
B-vitamins. Low levels of SAMe may lead indirectly to lowered serotonin production in the brain, causing depression. Research
studies show that supplemental SAMe elevates mood and reduces depression without such side effects as nervousness, headaches,
impotence, and sleep disturbance.
SAMe has also been shown to be beneficial in treating osteoarthritis, depression, and liver disease.