Product Information

Synonyms: pyridoxamine dihydrochloride, vitamin B-6 (amino form)

Keywords: aging, diabetes, hyperglycemia, AGEs, retinopathy, neuropathy, nephropathy, radiation poisoning


PrimAGE is a formulation containing two forms of vitamin B-6: pyridoxamine and pyridoxal-5'-phosphate (P5P). (Ordinary vitamin B-6 supplements usually consist of another form, called ‘pyridoxine’.) The P5P in our formula slows the body’s conversion of pyridoxamine to other substances, thereby prolonging its activity.

What we can’t tell you

In the U.S. and some other industrialized countries, government agencies like the U.S. Food and Drug Administration have adopted censorship as a method for intensifying their control over the supplement industry and its customers. Thus, FDA regulations prohibit us from telling you that any of our products are effective as medical treatments, even if they are, in fact, effective.

Accordingly, we will limit our discussion of PrimAGE™ to a brief summary of relevant research, and let you draw your own conclusions about what medical conditions it may be effective in treating.

Protein damage in aging and diabetes

While it has been known since the 1940s that pyridoxamine is a form of vitamin B-6, it was only recently that its unique and exciting properties came to light.1 In 1996 it was announced that pyridoxamine inhibits the formation of ‘Advanced Glycation End-products’ (AGEs).2

AGEs are damaged proteins — mainly structural proteins and enzymes — that have been bonded together by certain sugars in such a way as to impair their normal function. AGEs accumulate in the body as one ages,3 causing tissues to lose their elasticity and causing enzymes to malfunction. In fact, this accumulation of AGEs is considered to be one of the principal causes of aging.4

Aging, however, is not the only condition in which AGEs play a major role. Diabetes is another. Periods of high blood sugar (‘hyperglycemia’) are a hallmark of diabetes, and the resulting exposure of tissues to certain sugars (especially glucose) greatly increases the rate at which AGEs are formed. The accumulation of AGEs may account for much of the tissue damage that is seen in the diabetic state — including damage to kidneys (nephropathy), nerves (neuropathy), vasculature (atherosclerosis), and eyes (retinopathy, cataracts).5

Pyridoxamine and aging

Since aging is not officially recognized as a disease or medical condition by the FDA, we are free to tell you that pyridoxamine looks like an excellent agent for suppressing a major cause of aging. Here is the logic involved:

  • The accumulation of AGEs correlates with aging.3
  • AGEs cause some of the symptoms of aging, such as tissue stiffness and loss of function.6
  • Pyridoxamine inhibits the formation of AGEs.7
  • Therefore, pyridoxamine is likely to suppress some aspects of aging. Only a decades-long clinical study can demonstrate this conclusion beyond a shadow of a doubt, but few would be so foolish as to wait decades for such a study to be completed before going ahead and using pyridoxamine as an anti-aging supplement.
Pyridoxamine and diabetic symptoms

Here are some highlights of recent research into the connection between AGEs, diabetes, and pyridoxamine:

  • AGEs play a key role in the damage of tissues by sugars, such as glucose.6
  • The presence of diabetic complications correlates with elevated serum AGEs.8
  • Pyridoxamine inhibits the formation of AGEs ex vivo and in diabetic rats.9,10 (It is generally assumed that similar inhibition takes place in humans, although no studies have been done to prove it.)
  • Pyridoxamine protects against the development of nephropathy (kidney damage), retinopathy (damage to the retina), and neuropathy (nerve damage) in animal models of diabetes.7,11a,11b
  • Pyridoxamine slows kidney damage in diabetic patients.13 (The effects of pyridoxamine on diabetic neuropathy, retinopathy, and cardiovascular damage have not yet been studied in human clinical trials.)
Pyridoxamine and radiation poisoning

Exposure to high-energy particles, such as occurs after a nuclear power plant accident, can cause severe damage to living cells. The mechanism by which this occurs involves the collision of these particles with atoms in the cells — particularly atoms of oxygen. Oxygen atoms absorb some of the collision energy and are thereby put into a highly reactive state. Such energetically excited oxygen atoms then transfer their extra energy to chemical bonds of various kinds, causing destructive chemical reactions in proteins, DNA, lipids, and other biomolecules. Such altered biomolecules are then no longer able to function properly, and so the body's tissues and organs malfunction. Such damage tends to be permanent, debilitating, and if severe enough will be fatal.14

There is no effective overall treatment for radiation poisoning, although drastic measures like stem cell transplants can help to save lives in certain cases.

Until recently there was also no very effective method for preventing radiation poisoning other than avoiding exposure in the first place. However, in 2009 scientists at Vanderbilt University in the USA published a paper describing the use of pyridoxamine to block the cascade of events that starts with reactive oxygen and ends in damaged tissues.15 Pyridoxamine, it was shown, can neutralize reactive oxygen before it reacts with biomolecules. By preventing damage to biomolecules, it therefore prevents damage to tissues.

This does not mean that pyridoxamine fixes tissue damage that has already occurred. It does mean that if one is being subjected to continual radiation exposure, pyridoxamine can be used to decrease its damage to the body. Therefore:

  • Pyridoxamine is the best known preventative for ongoing radiation poisoning.

Are PrimAGE™ supplements useful for the conditions and purposes mentioned above? We aren’t allowed to tell you, so you should take a look at some of the references cited here, and then decide for yourself.

20505 200 mg 60 capsules 3 capsules $36.75
(13% off!)

Pronunciation: PrimAGE præm·ädžʹ

— RM

Last modified 2014.02.01