Product Information

High potency vitamin D3 with Zinc

Keywords: cholecalciferol, bone, osteoporosis, cancer, immunity, flu


D3ZO is a very high potency vitamin D3 supplement with zinc orotate — a combination that takes advantage of synergistic effects of these two supplements.

What is vitamin D3?

Vitamin D is a family of fat-soluble substances that are involved in the regulation of calcium usage, cell specialization, immunity, insulin secretion, blood pressure, and related processes.1

The most powerful form of vitamin D, in terms of the dosage required to fulfill the body’s needs, is vitamin D3 (aka. cholecalciferol). But regardless of which form one consumes, the vitamin is converted in the body to a substance that affects the activity of certain genes. Although the mechanism is complex, the consequences are easy to understand:

  • calcium and phosphorus levels in the blood are raised because vitamin D increases their absorption from food and decreases the elimination of calcium by the kidneys;
  • bone formation and mineralization are enhanced;
  • the parathyroid gland secretes more parathyroid hormone;
  • overactivity of the immune system is suppressed, while certain immune functions are promoted — such as anti-tumor activity.

Vitamin D3 is not made by plants. It is made in the skin of animals in response to ultraviolet light at wavelengths between 270–290 nm (UVB). For this reason, people who receive no sun exposure and who take no vitamin D supplements are at great risk of becoming vitamin D deficient — with grave consequences.

What we can’t tell you

In the U.S. and some other industrialized countries, government agencies like the U.S. Food and Drug Administration have adopted censorship as a method for intensifying their control over the supplement industry and its customers. Thus, FDA regulations prohibit us from telling you that any of our products are effective as medical treatments, even if they are, in fact, effective.

Accordingly, we will limit our discussion of D3ZO to a brief summary of relevant research, and let you draw your own conclusions about what medical conditions it may be effective in treating.

Vitamin D deficiency

Severe Vitamin D deficiency causes several bone diseases including:

  • rickets — defective growth of the long bones;
  • osteoporosis — reduced bone mineral density which leads to fragile bones;
  • osteomalacia — another bone-softening disorder that also causes muscle weakness.

Intake of less than 200 i.u. (5 mcg) per day of vitamin D2 carries a high risk of leading to bone diseases like those listed above. Dosages of 200 to 600 i.u. are officially recommended as supplements for adults for bone maintenance,2 but much higher doses are increasingly being viewed as desirable both for optimum bone health and for other purposes, such as preventing cancer.3,4

Vitamin D deficiencies may also be responsible for the severity of flu epidemics. A research group in the U.S. and New Zealand has found that some of the unexplained features of flu epidemics can be neatly accounted for by low vitamin D levels in the affected populations.17 The implications for public and individual health are enormous: the huge toll taken by influenza on society and on individuals may be avoidable if people simply start supplementing with higher doses of vitamin D.

Preventing osteoporosis

There is abundant statistical evidence indicating that in many parts of the world today the incidence of osteoporosis could be significantly reduced if people would consume an adequate amount of vitamin D. For example, an international study of vitamin D deficiency in osteoporosis patients in 18 countries showed that 64% of the patients had low vitamin D levels.5 A Japanese study in 2006 showed that the prevalence of insufficient vitamin D among frail, inactive elderly people in Japan was 50% greater than in independent community-dwelling elderly.6

Numerous clinical trials have demonstrated the efficacy of vitamin D supplemention in strengthening bones and preventing falls and fractures. These studies have shown that vitamin D3 is more effective than D2, and that daily dosages of at least 800 i.u. per day are needed to reduce fracture incidence by 65%.7

Preventing cancer

In a study published in 2007, daily supplementation with 1000 i.u. vitamin D was shown to reduce the colon cancer risk by 50%, and breast and ovarian cancer risks by 30%. It was estimated that reductions in overall cancer mortality rates could be 7% for males and 9% for females in the US and 14% for males and 20% for females in Western European countries below 59 degrees north latitude.8

A beneficial effect of high blood levels of the vitamin D metabolite calcitriol on patients with advanced prostate cancer has been shown.9

The Creighton Study, published in June 2007, reported a 77% reduction in new cancers in subjects given 1100 i.u. (27.5 mcg) per day of vitamin D3.10

Preventing influenza and other respiratory infections

No one knows the optimum dosage of vitamin D for preventing or ameliorating infections such as influenza. In view of this vitamin's impressive safety record, even at huge doses of hundreds of thousands of i.u./day, it seems reasonable to choose a fairly high dose, such as LifeLink's 25 thousand i.u. D3ZO capsules.

LifeLink does not subscribe to the idea that flu vaccines should be avoided. But we believe that vitamin D may offer a second line of defense when innoculations fail to provide adequate protection — which happens when rapidly mutating viral strains are involved, as they are, for example with Swine Flu.

Zinc orotate: an anti-aging osteo-enhancer

Zinc deficiency is believed to play a role in osteoporosis.11 The mechanism through which zinc enhances bone strength is not understood, but is likely to be independent of the mechanism through which vitamin D3 acts on bone. In such situations synergistic benefits are likely to occur when substances are used in combination.

There is a gene called ‘klotho’ that plays a central role both in the body’s calcium regulation and in aging.12,13 When this gene has low activity or is defective, the aging process is accelerated; when the gene is highly active, the aging process is slowed.14 Many people have less-than-optimal klotho gene activity, and high vitamin D levels can exacerbate this condition.15 Judging from mouse experiments, this problem is especially acute in females.16 But Japanese researchers reported in 2001 that supplementation with zinc orotate provides a ‘rescue’ from the consequences of low klotho activity, even in females.16

D3ZO therefore includes zinc orotate as a second active ingredient. LifeLink’s monograph on zinc orotate describes this supplement in more detail.

Cautionary note

This is a very high potency vitamin D3 supplement. Since vitamin D3 enhances the absorption of calcium and decreases its elimination by the kidneys, it is important not to use high-dose calcium supplements in combination with this product. Too much calcium in the blood can result in a condition called “hypercalcemia”, typical symptoms of which are weakness, loss of appetite, nausea, confusion, and lethargy. D3ZO is intended to enable users to get the bone benefits of mega-dose calcium supplements without having to take mega-doses of calcium.


Are D3ZO supplements useful for the conditions and purposes mentioned above? We aren’t allowed to tell you, so you should take a look at some of the references cited here, and then decide for yourself.

20115 625 mcg (25000 i.u.) 30 capsules 1 capsule $22.42
(11% off!)

Pronunciation: cholecalciferol ko′·lĕ·kal·sıf′·ə·rol

— RM

Last modified 2010.08.30